Dr. Marcelo Tolmasky
- Role: Professor of Biological Sciences
- Phone: (657) 278-5263
- Department: Department of Biological Science
Antimicrobial resistance is a growing problem that threatens treatment of infectious diseases and numerous medical procedures. A critical aspect of the fight against this problem is the search for strategies aimed at preserving the effectiveness of currently available drugs. Our model system is the aminoglycoside 6ʹ-N-acetyltransferase type Ib [AAC(6ʹ)-Ib], one of the the most clinically relevant acetyltransferases among gram-negative pathogens, which mediates resistance to important aminoglycosides. Our long term goal is to develop pharmacological tools that in combination with aminoglycosides overcome the presence of aac(6ʹ)-Ib and can be successfully used to treat resistant infections.